Package size

100 Tests, 50 Tests, 25 Tests, 10 Tests, 5 Tests, 100 Tests (N-QC), 50 Tests (N-QC), 25 Tests (N-QC), 10 Tests (N-QC), 5 Tests (N-QC).

Intended use

This device is intended to be used for the in vitro quantitative determination of C-Reactive Protein (CRP) and Serum Amyloid A (SAA) in human whole blood, peripheral blood, serum or plasma. And it is for professional use only, not for self-testing of untrained individuals, nor for near-patient testing.

Summary

C-reactive protein (CRP) is synthesized by hepatocytes. When the body is infected or tissue is damaged, macrophages and other leukocytes are activated to produce interleukin-6 (IL-6), interleukin-1 (IL-1), tumor necrosis factor TNF-a and other cytokines and other mediators, these cytokines and mediators reach the liver and stimulate hepatocytes and epithelial cells to synthesize C-reactive protein. Detection of C-reactive protein includes conventional C-reactive protein (conventional CRP) and high-sensitivity C-reactive protein (high-sensitivity CRP). The detection objects of the two are essentially the same, but the quantitative range of the detection methods is different. The concentration of conventional C-reactive protein can rapidly increase within a few hours of acute inflammation, and its increase is positively correlated with the degree of infection. It is a widely used as inflammatory marker and can be used to evaluate tissue damage and inflammatory diseases, and provide reference information for the diagnosis, treatment, and monitoring of disease. A common use of high-sensitivity C-reactive protein is as an aid in cardiovascular disease risk identification. Combined with the traditional clinical diagnosis of acute coronary syndrome, the high-sensitivity C-reactive protein result can be used as an early warning indicator of coronary artery disease or acute coronary syndrome recurrence. The detection range of full-range C-reactive protein (full-range CRP) covers the detection range of both conventional CRP and hypersensitive CRP.

Serum amyloid A (hereafter referred to as SAA) is an acute-phase protein whose concentration in the blood can rise sharply within hours during inflammatory, infectious and non-infectious diseases. The increase can reach 10-1000 times the normal value. After clearing the pathogen, it can be quickly reduced to normal level, which is a sensitive indicator reflecting the infection status of the body and the recovery of inflammation. Similar to C-reactive protein (hereafter referred to as CRP), the detection of SAA is helpful in diagnosing inflammation, assessing its activity, monitoring its activity, and treatment. However, it is more conclusive than the CRP test in diagnosing patients with viral infection, renal transplant rejection (especially those on immunosuppressive therapy), and patients with cystic fibrosis treated with corticosteroids. SAA is associated with high-density lipoprotein (HDL), which regulates high-density lipoprotein (HDL) metabolism during inflammation. A particularly important property of SAA is that its degradation products can be deposited in various organs in the form of amyloid A (AA) fibrils, which is a serious complication in chronic inflammatory diseases. The study found that in cases of inflammatory arthritis, SAA was most strongly associated with disease activity. For patients with amyloid A amyloidosis, treatment aimed at restoring serum amyloid A levels to normal can improve the condition.

In the early diagnosis of infectious diseases, the combined detection of SAA and CRP can provide early identification of viral and bacterial infections. When SAA and CRP increase at the same time, it indicates the possibility of bacterial infection; if SAA increases but CRP does not increase, it indicates the possibility of viral infection. Simultaneous detection of CRP and SAA can improve the sensitivity of infection diagnosis.

The current clinical methods for detecting CRP & SAA include chemiluminescence, immunochromatography and so on.

Hospitals

Laboratory

Clinics

Ambulance

Q: Is it possible to OEM?

A: Yes. Clients need to authorize brands and provide design solutions.

Q: How long is the usual delivery time?

A: The regular delivery time is about 2 weeks. If you need to do new packaging (OEM), the delivery time for the first order is 25-30 days, and the second order starts and the regular delivery time is the same.

Q: Are there any requirements for reagent storage? 

A: The storage temperature of our reagents is room temperature, 2-30℃

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